Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice

OBJECTIVES: To investigate the influence of low‐dose sildenafil, a phosphodiesterase type 5 inhibitor (PDE5‐I), on the function of the mouse lower urinary tract (LUT). MATERIALS AND METHODS: Adult male mice were decerebrated and arterially perfused with a carbogenated Ringer's solution to estab...

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Vydáno v:BJU Int
Hlavní autoři: Ito, Hiroki, Chakrabarty, Basu, Drake, Marcus J., Fry, Christopher H., Kanai, Anthony J., Pickering, Anthony E.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Translational Science
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579678/
https://ncbi.nlm.nih.gov/pubmed/30636087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bju.14664
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