Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

OBJECTIVES: To unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment response/outcomes longitudinally. METHODS: 144 consecutive treatment-naïve ea...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Humby, Frances, Lewis, Myles, Ramamoorthi, Nandhini, Hackney, Jason A, Barnes, Michael R, Bombardieri, Michele, Setiadi, A. Francesca, Kelly, Stephen, Bene, Fabiola, DiCicco, Maria, Riahi, Sudeh, Rocher, Vidalba, Ng, Nora, Lazarou, Ilias, Hands, Rebecca, van der Heijde, Désirée, Landewé, Robert B M, van der Helm-van Mil, Annette, Cauli, Alberto, McInnes, Iain, Buckley, Christopher Dominic, Choy, Ernest H, Taylor, Peter C, Townsend, Michael J, Pitzalis, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Rheumatoid Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579551/
https://ncbi.nlm.nih.gov/pubmed/30878974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-214539
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