The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration

The retinoid cycle is a metabolic process in the vertebrate retina that continuously regenerates 11-cis-retinal (11-cisRAL) from the all-trans-retinal (atRAL) isomer. atRAL accumulation can cause photoreceptor degeneration and irreversible visual dysfunction associated with incurable blinding retina...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Getter, Tamar, Suh, Susie, Hoang, Thanh, Handa, James T., Dong, Zhiqian, Ma, Xiuli, Chen, Yuanyuan, Blackshaw, Seth, Palczewski, Krzysztof
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2019
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579480/
https://ncbi.nlm.nih.gov/pubmed/31073029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008697
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