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Implants of Encapsulated Human CNTF-Producing Fibroblasts Prevent Behavioral Deficits and Striatal Degeneration in a Rodent Model of Huntington’s Disease

Delivery of neurotrophic molecules to the CNS has gained considerable attention as a potential treatment strategy for neurological disorders. In the present study, a DHFR-based expression vector containing the human ciliary neurotrophic factor (hCNTF) was transfected into a baby hamster kidney fibro...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Emerich, Dwaine F., Lindner, Mark D., Winn, Shelley R., Chen, Er-Yun, Frydel, Beata R., Kordower, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 1996
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579299/
https://ncbi.nlm.nih.gov/pubmed/8756445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.16-16-05168.1996
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