2′-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms

Bacterial RNA has emerged as an important activator of innate immune responses by stimulating Toll-like receptors TLR7 and TLR8 in humans. Guanosine 2′-O-methylation at position 18 (Gm18) in bacterial tRNA was shown to antagonize tRNA-induced TLR7/8 activation, suggesting a potential role of Gm18 as...

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Vydáno v:RNA
Hlavní autoři: Freund, Isabel, Buhl, Daniel K., Boutin, Sébastien, Kotter, Annika, Pichot, Florian, Marchand, Virginie, Vierbuchen, Tim, Heine, Holger, Motorin, Yuri, Helm, Mark, Dalpke, Alexander H., Eigenbrod, Tatjana
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573781/
https://ncbi.nlm.nih.gov/pubmed/31019095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.070243.118
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