Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis

5-aminolevulinic acid (5-ALA) has recently been employed for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various types of cancer because hyperproliferating tumor cells do not utilize oxidative phosphorylation and do not efficiently produce heme; instead, they accumulate pr...

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Published in:Sci Rep
Main Authors: Kitajima, Yuya, Ishii, Takuya, Kohda, Takeo, Ishizuka, Masahiro, Yamazaki, Kanami, Nishimura, Yumiko, Tanaka, Tohru, Dan, Shingo, Nakajima, Motowo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572817/
https://ncbi.nlm.nih.gov/pubmed/31209282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44981-y
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