Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists

Covalent agonists of PPARγ cause unique receptor conformational changes and behave as selective PPARγ modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based strategy to identify new PPARγ ligands and synt...

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Vydáno v:Molecules
Hlavní autoři: Utsugi, Yuki, Kobuchi, Hirona, Kawamura, Yukio, Atito, Ahmed Salahelden Aboelhamd, Nagao, Masaya, Isoda, Hiroko, Miyamae, Yusaku
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571965/
https://ncbi.nlm.nih.gov/pubmed/31137814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24102019
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