Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice

BACKGROUND: The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate (DOCA) hypertension was attenuated by sodium valproate, a pan-HDAC inhibitor. H...

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Vydáno v:Clin Hypertens
Hlavní autoři: Kee, Hae Jin, Ryu, Yuhee, Seok, Young Mi, Choi, Sin Young, Sun, Simei, Kim, Gwi Ran, Jeong, Myung Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570901/
https://ncbi.nlm.nih.gov/pubmed/31223486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40885-019-0118-8
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