High-throughput sequencing of IgG B-cell receptors reveals frequent usage of the rearranged IGHV4–28/IGHJ4 gene in primary immune thrombocytopenia

Primary immune thrombocytopenia (ITP) is an acquired form of thrombocytopenia caused by IgG anti-platelet autoantibodies and represents an organ-specific autoimmune disorder. Although the glycoprotein (GP)IIb/IIIa and GPIb/IX have been shown to be targets for autoantibodies, the antigen specificity...

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Publicado no:Sci Rep
Main Authors: Hirokawa, Makoto, Fujishima, Naohito, Togashi, Masaru, Saga, Akiko, Omokawa, Ayumi, Saga, Tomoo, Moritoki, Yuki, Ueki, Shigeharu, Takahashi, Naoto, Kitaura, Kazutaka, Suzuki, Ryuji
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570656/
https://ncbi.nlm.nih.gov/pubmed/31201346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45264-2
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