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Enhanced immunogenicity of a functional enzyme by T cell epitope modification

BACKGROUND: T helper epitopes are necessary for the induction of high titers of antigen-specific IgG antibodies. We are interested in the epitope modification of intact proteins as a method to enhance their immunogenicity for the generation of recombinant protein-based vaccines. RESULTS: Hartley str...

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Publicat a:BMC Immunol
Autors principals: Mucha, Jeanette M, Stickler, Marcia M, Poulose, AJ, Ganshaw, Grant, Saldajeno, Mae, Collier, Kathy, Huang, Manley T, Harding, Fiona A
Format: Artigo
Idioma:Inglês
Publicat: BMC 2002
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC65700/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11869454/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2172-3-2
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