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Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses
Spinal intrathecal injections of the nonsteroidal antiinflammatory analgesics (NSAIAs) indomethacin and acetylsalicylic acid, which inhibit prostaglandin synthesis, cause dose-dependent hypoalgesia in the rat. Intrathecal injections of prostaglandin-E2 (PGE2) produce dose- dependent hyperalgesia. To...
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| Publicado no: | J Neurosci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
1988
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6569250/ https://ncbi.nlm.nih.gov/pubmed/2833584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.08-04-01346.1988 |
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