Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death

BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation are primary resistant to EGFR-TKIs such as gefitinib. Curcumin has been k...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Chen, Ping, Huang, Han-Peng, Wang, Yi, Jin, Jun, Long, Wei-Guo, Chen, Kan, Zhao, Xiao-Hui, Chen, Chen-Guo, Li, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567416/
https://ncbi.nlm.nih.gov/pubmed/31196210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1234-8
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