Melanocortin-4 Receptor and Lipocalin 2 Gene Variants in Spanish Children with Abdominal Obesity: Effects on BMI-SDS after a Lifestyle Intervention

Mutations leading to a reduced function of the melanocortin-4 receptor (MC4R) exert a major gene effect on extreme obesity. Recently it was shown that the bone derived hormone lipocalin 2 (LCN2) binds to the MC4R and activates a MC4R dependent anorexigenic pathway. We identified mutations in both ge...

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Veröffentlicht in:Nutrients
Hauptverfasser: Morell-Azanza, Lydia, Ojeda-Rodríguez, Ana, Giuranna, Johanna, Azcona-SanJulián, Mª Cristina, Hebebrand, Johannes, Marti, Amelia, Hinney, Anke
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566731/
https://ncbi.nlm.nih.gov/pubmed/31035493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu11050960
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