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Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment
The effect of mutations in individual proteins on protein homeostasis, or “proteostasis,” can in principle depend on the mutations' effects on the thermodynamics or kinetics of folding, or both. Here, we explore this issue using a computational model of in vivo protein folding that we call Fold...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6566562/ https://ncbi.nlm.nih.gov/pubmed/31074892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3639 |
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