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Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development

The epidermal barrier is thought to protect sensory nerves from overexposure to environmental stimuli, and barrier impairment leads to pathological conditions associated with itch, such as atopic dermatitis (AD). However, it is not known how the epidermal barrier continuously protects nerves for the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Takahashi, Sonoko, Ishida, Azusa, Kubo, Akiharu, Kawasaki, Hiroshi, Ochiai, Sotaro, Nakayama, Manabu, Koseki, Haruhiko, Amagai, Masayuki, Okada, Takaharu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6565750/
https://ncbi.nlm.nih.gov/pubmed/31197234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44866-0
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