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Locus ceruleus lesion by local 6-hydroxydopamine infusion causes marked and specific destruction of noradrenergic neurons, long-term depletion of norepinephrine and the enzymes that synthesize it, and enhanced dopaminergic mechanisms in the ipsilateral cerebral cortex
The local stereotaxic microinfusion of 5 micrograms of 6- hydroxydopamine in the region of the nucleus locus ceruleus causes severe loss of noradrenergic neurons with little evidence of nonspecific tissue reaction or destruction that could be detected by conventional light microscopic methods. Such...
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| Pubblicato in: | J Neurosci |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
1984
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6564819/ https://ncbi.nlm.nih.gov/pubmed/6142931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.04-03-00699.1984 |
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