Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

During rheumatoid arthritis (RA) treatment, long-term injection of antitumor necrosis factor α antibodies (anti-TNFα Abs) may induce on-target toxicities, including severe infections (tuberculosis [TB] or septic arthritis) and malignancy. Here, we used an immunoglobulin G1 (IgG1) hinge as an Ab lock...

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Pubblicato in:PLoS Biol
Autori principali: Lu, Yun-Chi, Chuang, Chih-Hung, Chuang, Kuo-Hsiang, Chen, I-Ju, Huang, Bo-Cheng, Lee, Wen-Han, Wang, Hsin-Ell, Li, Jia-Je, Cheng, Yi-An, Cheng, Kai-Wen, Wang, Jaw-Yuan, Hsieh, Yuan-Chin, Lin, Wen-Wei, Cheng, Tian-Lu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563948/
https://ncbi.nlm.nih.gov/pubmed/31194726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000286
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