Enterovirus A71 VP1 Variation A289T Decreases the Central Nervous System Infectivity via Attenuation of Interactions between VP1 and Vimentin In Vitro and In Vivo

Vimentin (VIM) is a surface receptor for enterovirus-A71, mediating the initial binding and subsequent increase in EV-A71 infectivity. The caspid protein VP1 variation, A289T, is reportedly closely associated with less severe central nervous system (CNS) infections in humans. However, it is unclear...

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Detalhes bibliográficos
Publicado no:Viruses
Main Authors: Zhu, Huimin, Cao, Yujuan, Su, Weitao, Huang, Shan, Lu, Weizhi, Zhou, Yezhen, Gao, Jing, Zhao, Wei, Zhang, Bao, Wu, Xianbo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563288/
https://ncbi.nlm.nih.gov/pubmed/31121933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v11050467
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