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Modulating PKCα Activity to Target Wnt/β-Catenin Signaling in Colon Cancer
Inactivating mutations of the tumor suppressor Adenomatosis Polyposis Coli (APC), which are found in familial adenomatosis polyposis and in 80% of sporadic colorectal cancers (CRC), result in constitutive activation of the Wnt/β-catenin pathway and tumor development in the intestine. These mutations...
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| Publicado no: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6563011/ https://ncbi.nlm.nih.gov/pubmed/31109112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050693 |
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