Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer’s Disease Therapeutic Development

As genome-wide association studies (GWAS) have grown in size, the number of genetic variants that have been associated per disease has correspondingly increased. Despite this increase in the number of single-nucleotide polymorphisms (SNPs) identified per disease, their biological interpretation has...

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Pubblicato in:Cells
Autori principali: Nevado-Holgado, Alejo J., Ribe, Elena, Thei, Laura, Furlong, Laura, Mayer, Miguel-Angel, Quan, Jie, Richardson, Jill C., Cavanagh, Jonathan, Lovestone, Simon
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562942/
https://ncbi.nlm.nih.gov/pubmed/31072055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8050425
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