A Transgenic Mouse Model of Pacak–Zhuang Syndrome with An Epas1 Gain-of-Function Mutation

We previously identified a novel syndrome in patients characterized by paraganglioma, somatostatinoma, and polycythemia. In these patients, polycythemia occurs long before any tumor develops, and tumor removal only partially corrects polycythemia, with recurrence occurring shortly after surgery. Gen...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Wang, Herui, Cui, Jing, Yang, Chunzhang, Rosenblum, Jared S., Zhang, Qi, Song, Qi, Pang, Ying, Fang, Francia, Sun, Mitchell, Dmitriev, Pauline, Gilbert, Mark R., Eisenhofer, Graeme, Pacak, Karel, Zhuang, Zhengping
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562734/
https://ncbi.nlm.nih.gov/pubmed/31091718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050667
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