The Significant Reduction or Complete Eradication of Subcutaneous and Metastatic Lesions in a Pheochromocytoma Mouse Model after Immunotherapy Using Mannan-BAM, TLR Ligands, and Anti-CD40

Therapeutic options for metastatic pheochromocytoma/paraganglioma (PHEO/PGL) are limited. Here, we tested an immunotherapeutic approach based on intratumoral injections of mannan-BAM with toll-like receptor ligands into subcutaneous PHEO in a mouse model. This therapy elicited a strong innate immuni...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Caisova, Veronika, Li, Liping, Gupta, Garima, Jochmanova, Ivana, Jha, Abhishek, Uher, Ondrej, Huynh, Thanh-Truc, Miettinen, Markku, Pang, Ying, Abunimer, Luma, Niu, Gang, Chen, Xiaoyuan, Ghayee, Hans Kumar, Taïeb, David, Zhuang, Zhengping, Zenka, Jan, Pacak, Karel
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562455/
https://ncbi.nlm.nih.gov/pubmed/31083581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11050654
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