Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection

Glucocorticoids (Gcs) are widely prescribed anti-inflammatory compounds, which act through the glucocorticoid receptor (GR). Using an unbiased proteomics screen in lung tissue, we identified the membrane protein caveolin -1 (Cav1) as a direct interaction partner of the GR. In Cav1 knockout mice GR t...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Caratti, G., Poolman, T., Hurst, R. J., Ince, L., Knight, A., Krakowiak, K., Durrington, H. J., Gibbs, J., Else, K. J., Matthews, L. C., Ray, D. W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562044/
https://ncbi.nlm.nih.gov/pubmed/31189975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44963-0
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