Infiltrating CCR2(+) monocytes and their progenies, fibrocytes, contribute to colon fibrosis by inhibiting collagen degradation through the production of TIMP-1

Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence of intestinal fibrosis and need for bowel resection have not significantly changed. To clarify the contribution of haematopoietic...

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Publicado en:Sci Rep
Autores principales: Kuroda, Naoki, Masuya, Masahiro, Tawara, Isao, Tsuboi, Junya, Yoneda, Misao, Nishikawa, Kenichiro, Kageyama, Yuki, Hachiya, Kensuke, Ohishi, Kohshi, Miwa, Hiroshi, Yamada, Reiko, Hamada, Yasuhiko, Tanaka, Kyosuke, Kato, Takuma, Takei, Yoshiyuki, Katayama, Naoyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6562037/
https://ncbi.nlm.nih.gov/pubmed/31189971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45012-6
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