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Proteomic Profiling, Transcription Factor Modeling, and Genomics of Evolved Tolerant Strains Elucidate Mechanisms of Vanillin Toxicity in Escherichia coli

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is an economically important flavor compound that can be made in bacterial cell factories, but toxicity is a major problem for cells producing this aromatic aldehyde. Using (i) a global proteomic analysis supported by multiple physiological experiments, mut...

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Detalhes bibliográficos
Publicado no:mSystems
Main Authors: Pattrick, Calum A., Webb, Joseph P., Green, Jeffrey, Chaudhuri, Roy R., Collins, Mark O., Kelly, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561319/
https://ncbi.nlm.nih.gov/pubmed/31186336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00163-19
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