Role for polo-like kinase 4 in mediation of cytokinesis

The mitotic protein polo-like kinase 4 (PLK4) plays a critical role in centrosome duplication for cell division. By using immunofluorescence, we confirm that PLK4 is localized to centrosomes. In addition, we find that phospho-PLK4 (pPLK4) is cleaved and distributed to kinetochores (metaphase and ana...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Press, Michael F., Xie, Bin, Davenport, Simon, Zhou, Yu, Guzman, Roberta, Nolan, Garry P., O’Brien, Neil, Palazzolo, Michael, Mak, Tak W., Brugge, Joan S., Slamon, Dennis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561306/
https://ncbi.nlm.nih.gov/pubmed/31097597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818820116
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