Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing

Hair cells, the sensory receptors of the inner ear, respond to mechanical forces originating from sounds and accelerations. An essential feature of each hair cell is an array of filamentous tip links, consisting of the proteins protocadherin 15 (PCDH15) and cadherin 23 (CDH23), whose tension is thou...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bartsch, Tobias F., Hengel, Felicitas E., Oswald, Aaron, Dionne, Gilman, Chipendo, Iris V., Mangat, Simranjit S., El Shatanofy, Muhammad, Shapiro, Lawrence, Müller, Ulrich, Hudspeth, A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561218/
https://ncbi.nlm.nih.gov/pubmed/31072932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902163116
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