The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

The emergence of fluoroquinolone resistance in nosocomial pathogens has restricted the clinical efficacy of this antibiotic class. In Acinetobacter baumannii, the majority of clinical isolates now show high-level resistance due to mutations in gyrA (DNA gyrase) and parC (topoisomerase IV [topo IV])....

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Bibliographic Details
Published in:mBio
Main Authors: Geisinger, Edward, Vargas-Cuebas, Germán, Mortman, Nadav J., Syal, Sapna, Dai, Yunfei, Wainwright, Elizabeth L., Lazinski, David, Wood, Stephen, Zhu, Zeyu, Anthony, Jon, van Opijnen, Tim, Isberg, Ralph R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561030/
https://ncbi.nlm.nih.gov/pubmed/31186328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01127-19
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