Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

AIMS/HYPOTHESIS: The aim of this study was to elucidate the impact of 3′-phosphoinositide-dependent protein kinase-1 (PDPK1) in vascular endothelial cells on the maintenance of pancreatic beta cell mass and function. METHODS: Male vascular endothelial cell-specific Pdpk1-knockout mice (Tie2(+/−)/Pdp...

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Bibliografski detalji
Izdano u:Diabetologia
Glavni autori: Obata, Atsushi, Kimura, Tomohiko, Obata, Yoshiyuki, Shimoda, Masashi, Kinoshita, Tomoe, Kohara, Kenji, Okauchi, Seizo, Hirukawa, Hidenori, Kamei, Shinji, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560212/
https://ncbi.nlm.nih.gov/pubmed/31055616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-4878-1
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