Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independent ovarian cancer cell senescence defined by senescence-as...

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Pubblicato in:Nat Commun
Autori principali: Fleury, Hubert, Malaquin, Nicolas, Tu, Véronique, Gilbert, Sophie, Martinez, Aurélie, Olivier, Marc-Alexandre, Sauriol, Skye Alexandre, Communal, Laudine, Leclerc-Desaulniers, Kim, Carmona, Euridice, Provencher, Diane, Mes-Masson, Anne-Marie, Rodier, Francis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560032/
https://ncbi.nlm.nih.gov/pubmed/31186408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10460-1
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