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Modeling in-vivo protein-DNA binding by combining multiple-instance learning with a hybrid deep neural network

Modeling in-vivo protein-DNA binding is not only fundamental for further understanding of the regulatory mechanisms, but also a challenging task in computational biology. Deep-learning based methods have succeed in modeling in-vivo protein-DNA binding, but they often (1) follow the fully supervised...

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Pubblicato in:Sci Rep
Autori principali: Zhang, Qinhu, Shen, Zhen, Huang, De-Shuang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559991/
https://ncbi.nlm.nih.gov/pubmed/31186519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44966-x
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