Kinetic model for adherent Vero cell growth and poliovirus production in batch bioreactors

The production of poliovirus vaccines in adherent Vero cells in batch bioreactors usually consists of a two-step upstream process: (1) Vero cell cultivation on microcarriers and (2) poliovirus proliferation. In this study we developed a mathematical model to describe this two-step process. We introd...

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Publicado en:Process Biochem
Autores principales: Jiang, Yang, van der Welle, Joyce E., Rubingh, Olaf, van Eikenhorst, Gerco, Bakker, Wilfried A.M., Thomassen, Yvonne E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Applied Science 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559155/
https://ncbi.nlm.nih.gov/pubmed/31217725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.procbio.2019.03.010
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