Haploidentical CD19/CD22 bispecific CAR-T cells induced MRD-negative remission in a patient with relapsed and refractory adult B-ALL after haploidentical hematopoietic stem cell transplantation

BACKGROUND: Chimeric antigen receptor T (CAR-T) cell therapy simultaneously against CD19 and CD22 is an attractive strategy to address the antigen escape relapse after CD19-directed CAR-T cell therapies. However, the potential of optimizing the durability of remission by this approach in patients wi...

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Bibliographische Detailangaben
Veröffentlicht in:J Hematol Oncol
Hauptverfasser: Jia, Hejin, Wang, Zhenguang, Wang, Yao, Liu, Yang, Dai, Hanren, Tong, Chuan, Guo, Yelei, Guo, Bo, Ti, Dongdong, Han, Xiao, Yang, Qingming, Wu, Zhiqiang, Han, Weidong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Case Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558895/
https://ncbi.nlm.nih.gov/pubmed/31182121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0741-6
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