Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans

Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ci...

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Pubblicato in:Front Physiol
Autori principali: Knöpfel, Emilia Boiadjieva, Vilches, Clara, Camargo, Simone M. R., Errasti-Murugarren, Ekaitz, Stäubli, Andrina, Mayayo, Clara, Munier, Francis L., Miroshnikova, Nataliya, Poncet, Nadège, Junza, Alexandra, Bhattacharya, Shomi S., Prat, Esther, Berry, Vanita, Berger, Wolfgang, Heon, Elise, Moore, Anthony T., Yanes, Óscar, Nunes, Virginia, Palacín, Manuel, Verrey, Francois, Kloeckener-Gruissem, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Physiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558864/
https://ncbi.nlm.nih.gov/pubmed/31231240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00688
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