Generation of tumor-reactive T cells by co-culture of peripheral blood lymphocytes and tumor organoids

Cancer immunotherapies have shown substantial clinical activity for a subset of patients with epithelial cancers. Still, technological platforms to study cancer – T cell interactions for individual patients, and understand determinants of responsiveness, are presently lacking. Here, we establish and...

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Publicado no:Cell
Main Authors: Dijkstra, Krijn K., Cattaneo, Chiara M., Weeber, Fleur, Chalabi, Myriam, van de Haar, Joris, Fanchi, Lorenzo F., Slagter, Maarten, van der Velden, Daphne L., Kaing, Sovann, Kelderman, Sander, van Rooij, Nienke, van Leerdam, Monique E., Depla, Annekatrien, Smit, Egbert F., Hartemink, Koen J., de Groot, Rosa, Wolkers, Monika C., Sachs, Norman, Snaebjornsson, Petur, Monkhorst, Kim, Haanen, John, Clevers, Hans, Schumacher, Ton N., Voest, Emile E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558289/
https://ncbi.nlm.nih.gov/pubmed/30100188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.07.009
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