Identifying and targeting cancer-specific metabolism with network-based drug target prediction

BACKGROUND: Metabolic rewiring allows cancer cells to sustain high proliferation rates. Thus, targeting only the cancer-specific cellular metabolism will safeguard healthy tissues. METHODS: We developed the very efficient FASTCORMICS RNA-seq workflow (rFASTCORMICS) to build 10,005 high-resolution me...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Pacheco, Maria Pires, Bintener, Tamara, Ternes, Dominik, Kulms, Dagmar, Haan, Serge, Letellier, Elisabeth, Sauter, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558238/
https://ncbi.nlm.nih.gov/pubmed/31126892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.04.046
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