Reduced IL-2 response from peripheral blood mononuclear cells exposed to bacteria at 6 months of age is associated with elevated total-IgE and allergic rhinitis during the first 7 years of life

BACKGROUND: Autoimmunity and allergy have been associated with decreased number and function of regulatory T-cells (Tregs) and low interleukin-2 (IL-2) levels. We aimed to investigate if the release of IL-2 from peripheral blood mononuclear cells (PBMCs) stimulated with pathogenic airway bacteria wa...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Wang, Ni, Schoos, Ann-Marie M., Larsen, Jeppe M., Brix, Susanne, Thysen, Anna H., Rasmussen, Morten A., Stokholm, Jakob, Bønnelykke, Klaus, Bisgaard, Hans, Chawes, Bo L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558232/
https://ncbi.nlm.nih.gov/pubmed/31056472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.04.047
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