Unveiling the Diversity of Immunoglobulin Heavy Constant Gamma (IGHG) Gene Segments in Brazilian Populations Reveals 28 Novel Alleles and Evidence of Gene Conversion and Natural Selection

Even though immunoglobulins are critical for immune responses and human survival, the diversity of the immunoglobulin heavy chain gene (IGH) is poorly known and mostly characterized only by serological methods. Moreover, this genomic region is not well-covered in genomic databases and genome-wide as...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Calonga-Solís, Verónica, Malheiros, Danielle, Beltrame, Marcia Holsbach, Vargas, Luciana de Brito, Dourado, Renata Montoro, Issler, Hellen Caroline, Wassem, Roseli, Petzl-Erler, Maria Luiza, Augusto, Danillo G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558194/
https://ncbi.nlm.nih.gov/pubmed/31214166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01161
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