Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2

After Salmonella is phagocytosed, it resides in an acidic vacuole. Its cytoplasm acidifies to pH 5.6; acidification activates pathogenicity island 2 (SPI-2). SPI-2 encodes a type three secretion system whose effectors modify the vacuole, driving endosomal tubulation. Using super-resolution imaging i...

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Bibliographic Details
Published in:eLife
Main Authors: Liew, Andrew Tze Fui, Foo, Yong Hwee, Gao, Yunfeng, Zangoui, Parisa, Singh, Moirangthem Kiran, Gulvady, Ranjit, Kenney, Linda J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2019
Subjects:
Microbiology and Infectious Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557628/
https://ncbi.nlm.nih.gov/pubmed/31033442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45311
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