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Single cell, super-resolution imaging reveals an acid pH-dependent conformational switch in SsrB regulates SPI-2
After Salmonella is phagocytosed, it resides in an acidic vacuole. Its cytoplasm acidifies to pH 5.6; acidification activates pathogenicity island 2 (SPI-2). SPI-2 encodes a type three secretion system whose effectors modify the vacuole, driving endosomal tubulation. Using super-resolution imaging i...
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| Published in: | eLife |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
eLife Sciences Publications, Ltd
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6557628/ https://ncbi.nlm.nih.gov/pubmed/31033442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45311 |
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