Engineered bacteriophages for treatment of a patient with a disseminated drug resistant Mycobacterium abscessus

A 15-year-old cystic fibrosis patient with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineerin...

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Udgivet i:Nat Med
Main Authors: Dedrick, Rebekah M., Guerrero-Bustamante, Carlos A., Garlena, Rebecca A., Russell, Daniel A., Ford, Katrina, Harris, Kathryn, Gilmour, Kimberly C., Soothill, James, Jacobs-Sera, Deborah, Schooley, Robert T., Hatfull, Graham F., Spencer, Helen
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557439/
https://ncbi.nlm.nih.gov/pubmed/31068712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0437-z
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