Discovery of a Branched Peptide that Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication

We synthesized and screened a unique 46,656-member library composed of unnatural amino acids that revealed several hits against RRE IIB RNA. Among the hit peptides identified, peptide 4A5 was found to be selective against competitor RNAs and inhibited HIV-1 Rev-RRE RNA interaction in cell culture in...

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Publicado en:J Med Chem
Autores principales: Dai, Yumin, Wynn, Jessica E., Peralta, Ashley N., Sherpa, Chringma, Jayaraman, Bhargavi, Li, Hao, Verma, Astha, Frankel, Alan D., Le Grice, Stuart F., Santos, Webster L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557124/
https://ncbi.nlm.nih.gov/pubmed/30289719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01076
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