Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts

Wharton's jelly mesenchymal stem cells (WJMSCs) transfer healthy mitochondria to cells harboring a mitochondrial DNA (mtDNA) defect. Mitochondrial myopathy, encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is one of the major subgroups of mitochondrial diseases, caused by th...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Lin, Tsu-Kung, Chen, Shang-Der, Chuang, Yao-Chung, Lan, Min-Yu, Chuang, Jiin-Haur, Wang, Pei-Wen, Hsu, Te-Yao, Wang, Feng-Sheng, Tsai, Meng-Han, Huang, Sheng-Teng, Wang, Xiao-Wen, Tsai, Po-Chin, Lin, Hung-Yu, Liou, Chia-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556302/
https://ncbi.nlm.nih.gov/pubmed/31249652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9537504
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