Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes

OBJECT: To explore the mechanisms of ovarian aging, we performed overall analysis on the age-related alterations of gene expression profiles in mouse germinal vesicle (GV) stage oocytes by means of single-cell RNA-sequencing method (scRNA-seq). METHODS: Two age groups (5-week-old and 32-week-old) fe...

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Bibliographic Details
Published in:J Ovarian Res
Main Authors: Zhang, Tao, Xi, Qingsong, Wang, Dan, Li, Jingjing, Wang, Meng, Li, Dan, Zhu, Lixia, Jin, Lei
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556043/
https://ncbi.nlm.nih.gov/pubmed/31176373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-019-0529-x
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