Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

OBJECTIVES: Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no approved therapies directly target this activated subset of macrophages. METHO...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Hu, Yingwen, Wang, Bingbing, Shen, Jiayin, Low, Stewart A., Putt, Karson S., Niessen, Hans W. M., Matteson, Eric L., Murphy, Linda, Ruppert, Clemens, Jansen, Gerrit, Oliver, Stephen J., Feng, Yang, Dimitrov, Dimiter S., Nickerson-Nutter, Cheryl, Low, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555977/
https://ncbi.nlm.nih.gov/pubmed/31174578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1912-0
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