Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices

BACKGROUND: Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PAH). Moreover, TKIs relax pulmonary vessels of rats and guinea pigs. So far, it...

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發表在:Respir Res
Main Authors: Rieg, Annette D., Bünting, Nina A., Cranen, Christian, Suleiman, Said, Spillner, Jan W., Schnöring, Heike, Schröder, Thomas, von Stillfried, Saskia, Braunschweig, Till, Manley, Paul W., Schälte, Gereon, Rossaint, Rolf, Uhlig, Stefan, Martin, Christian
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555704/
https://ncbi.nlm.nih.gov/pubmed/31170998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1074-2
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