REC114 partner ANKRD31 controls number, timing and location of meiotic DNA breaks

Double-strand breaks (DSBs) initiate the homologous recombination that is crucial for meiotic chromosome pairing and segregation. Here we unveil mouse ANKRD31 as a lynchpin governing multiple aspects of DSB formation. Spermatocytes lacking ANKRD31 have altered DSB locations and fail to target DSBs t...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Boekhout, Michiel, Karasu, Mehmet E., Wang, Juncheng, Acquaviva, Laurent, Pratto, Florencia, Brick, Kevin, Eng, Diana Y., Xu, Jiaqi, Camerini-Otero, R. Daniel, Patel, Dinshaw J., Keeney, Scott
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555648/
https://ncbi.nlm.nih.gov/pubmed/31003867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.023
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