Temporal regulation of the bacterial metabolite deoxycholate during colonic repair is critical for crypt regeneration

Colonic wound repair is an orchestrated process beginning with barrier re-establishment followed by wound channel formation and crypt regeneration. Elevated levels of Prostaglandin E2 (PGE2) promote barrier re-establishment; however, we found that persistently elevated PGE2 hinders subsequent repair...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Jain, Umang, Lai, Chin-Wen, Xiong, Shanshan, Goodwin, Victoria M., Lu, Qiuhe, Muegge, Brian D., Christophi, George P., VanDussen, Kelli L., Cummings, Bethany P., Young, Erick, Hambor, John, Stappenbeck, Thaddeus S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555552/
https://ncbi.nlm.nih.gov/pubmed/30122655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2018.07.019
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