Genetic analyses led to the discovery of a super-active mutant of the RNA polymerase I

Most transcriptional activity of exponentially growing cells is carried out by the RNA Polymerase I (Pol I), which produces a ribosomal RNA (rRNA) precursor. In budding yeast, Pol I is a multimeric enzyme with 14 subunits. Among them, Rpa49 forms with Rpa34 a Pol I-specific heterodimer (homologous t...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Darrière, Tommy, Pilsl, Michael, Sarthou, Marie-Kerguelen, Chauvier, Adrien, Genty, Titouan, Audibert, Sylvain, Dez, Christophe, Léger-Silvestre, Isabelle, Normand, Christophe, Henras, Anthony K., Kwapisz, Marta, Calvo, Olga, Fernández-Tornero, Carlos, Tschochner, Herbert, Gadal, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555540/
https://ncbi.nlm.nih.gov/pubmed/31136569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008157
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