Vaccination of hamsters with Opisthorchis viverrini extracellular vesicles and vesicle-derived recombinant tetraspanins induces antibodies that block vesicle uptake by cholangiocytes and reduce parasite burden after challenge infection

BACKGROUND: The liver fluke Opisthorchis viverrini infects several million people in Southeast Asia. Adult flukes live in the bile ducts of humans, where they cause hepatobiliary pathology, including cholangiocarcinoma. Here, we investigated the potential of extracellular vesicles (EVs) secreted by...

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Veröffentlicht in:PLoS Negl Trop Dis
Hauptverfasser: Chaiyadet, Sujittra, Sotillo, Javier, Krueajampa, Watchara, Thongsen, Sophita, Brindley, Paul J., Sripa, Banchob, Loukas, Alex, Laha, Thewarach
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555531/
https://ncbi.nlm.nih.gov/pubmed/31136572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007450
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