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OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program

A paradox is posed by metazoan gene-regulatory networks (GRNs) that are robust yet evolvable. Insight may be obtained through studies of bistable genetic circuits mediating developmental decisions. A model in organogenesis is provided by the sex-specific differentiation of the embryonic gonadal ridg...

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Опубликовано в: :J Endocr Soc
Главные авторы: Chen, Yen-Shan, Racca, Joseph, Phillips, Nelson, Weiss, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555045/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/js.2019-OR15-5
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